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TN2 online lunch series - 20 May 2021
- 12.30 - 13.00 PM
Dr. Janne Papma (Alzheimer Center Erasmus Medical Center) - The role of neuroimaging in (frontotemporal) dementia prediction and dementia diagnostics

- 13.00 - 13.30 PM
Dr. Prejaas Tewarie (Amsterdam UMC, location Vumc) - Functional brain networks in multiple sclerosis

Read more below or on our website www.tn2.eu

Contact information: conference@tn2.eu

May 20, 2021 12:15 PM in Amsterdam

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Janne Papma
Dr, assistant professor @Alzheimer Center Erasmus Medical Center
Frontotemporal dementia (FTD) is a young onset type of dementia, characterized by an atrophy pattern involving the frontal and temporal lobes, resulting in behavioral changes and/or language difficulties. FTD is caused by an autosomal dominant genetic mutation in a third of all patients. Studying autosomal dominant FTD in the time period before symptoms arise (presymptomatic), enables us to examine the earliest stages of the disease process. In the FTD-RisC study, we follow presymptomatic FTD patients and their healthy family members into the disease stage. In this study population we have identified longitudinal neurodegenerative neuroimaging patterns, and correlated these to the first clinical changes. In the lecture I will focus on neuroimaging research performed in our presymptomatic FTD cohort, and in our clinical practice. Neuroimaging biomarkers identified in these studies can be used measuring the effectivity of clinical trials, and in early (differential) diagnostics.
Prejaas Tewarie
Dr. physician, Neurology @Amsterdam UMC, location VUmc
Normal brain function and cognition requires the interaction or communication between spatially separated brain regions. This so called functional connectivity emerges from neuronal dynamics and the underlying anatomical connections. Understanding the relationship between the anatomical white matter connections and emerging functional connectivity patterns is important to understand cognition in healthy subjects but also required to elucidate the result of structural damage in neurological disorders such as mutltiple sclerosis at the functional level. I will discuss recent advances in the field of functional connectivity, the relationship between structural and functional networks and the use of network theory in relation to the clinic radiological paradox in multiple sclerosis.