Chronic, low-grade sterile inflammation that occurs with age (inflammaging) has been observed in all mammalian species studied, from rodents to non-human primates to humans. It has been argued that aging is driven by the age-related increase in proinflammatory cytokines and substances produced by the innate immune system leading to reduced healthspan and accelerated aging.
Because inflammation is strongly associated with a variety of diseases (e.g. type 2 diabetes, cardiovascular disease, cancer, neurodegenerative diseases such as Alzheimer’s disease, and frailty), inflammaging appears to be an important factor in the etiology of most age-related diseases.
The webinar will provide participants with information about how inflammation influences aging and health as well as processes and mechanisms that facilitate, or inhibit, increasing chronic inflammation with age.
In this free webinar, presenters from the recent Oklahoma Geroscience Symposium will discuss:
• The relationship between the biology of aging and inflammatory responses
• Pathways leading to inflammation
• Inflammation and age-associated disease
• Senescence, the microbiome, and blood inflammatory mediators and aging
• Interventions to prevent inflammaging
Each expert will briefly present different perspectives on inflammaging. A Q&A will follow.
Dawn Bowdish, Ph.D.
Associate Professor of Pathology and Molecular Medicine, McMaster University
Luigi Ferrucci, M.D., Ph.D.
Scientific Director of the Intramural Research Program, National Institute on Aging
James Kirkland, M.D., Ph.D.
Professor of Medicine and Director of the Kogod Center on Aging, Mayo Clinic
Steven N. Austad, Ph.D.
Co-Principal Investigator of the Nathan Shock Centers Coordinating Center and Director of the Nathan Shock Center at the University of Alabama Birmingham
Arlan Richardson, Ph.D.
Director of the Oklahoma Nathan Shock Aging Center