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Early-Career Researchers Advancing 21st Century Science Webinar Series
Wednesday, November 4th 2020
1:00-2:30 pm ET

Modeling Cancer in 3 Dimensions Using Patient-Derived 3D Cultures, presented by Pilar de la Puente, PhD

Lack of efficacy and a low overall success rate of phase I-II clinical trials are the most common failures when it comes to advancing cancer treatment. We have developed a patient-derived 3D culture model to overcome these limitations in breast cancer. Our patient-derived model is capable of supporting the growth and expansion of primary tumors recapitulating the tumor microenvironment constituents and modeling cancer treatment responses to predict clinically effective drug treatment concentrations.

Validating the Environmental Exposure Unit as an Experimental Clinical Model for Perennial Allergic Rhinitis, presented by Lubnaa Hossenbaccus

The Environmental Exposure Unit (EEU) is a controlled allergen exposure facility housed in the Kingston Health Sciences Centre in Kingston, Canada. It is one of a number of controlled allergen challenge facilities (CACFs) around the world used to study allergic rhinitis (AR). AR is an inflammatory disease of the nasal mucosa triggered by allergen exposure. While seasonal allergens such as ragweed have previously been investigated in the EEU, house dust mite, a perennial allergen, has yet to be studied.

For further information, please visit: www.pcrm.org/ERA21

Nov 4, 2020 01:00 PM in Eastern Time (US and Canada)

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Pilar de la Puente, PhD
Dr. De la Puente received her PhD at University of Salamanca in Spain in Biomedical Engineering and Biological Sciences. The scope of her studies was the development of novel autologous cell culture in a biocompatible matrix enriched with growth factors for tissue engineering applications. She focused on the recreation of the tumor microenvironment of hematological malignancies during her postdoctoral fellow at Washington University in St Louis School of Medicine. She is an Assistant Professor at Sanford Research/University of South Dakota Sanford School of Medicine where she studies the role of tumor microenvironment in cancer progression, drug resistance and cancer immunology. Her lab is developing 3D models of the tumor microenvironment in order to more accurately mimic cell-cell and cell-matrix interactions for personalized medicine. She was awarded the Young Investigator Lush Prize in 2018 and is an active entrepreneur with several patents and roles on start-up companies.
Lubnaa Hossenbaccus
Lubnaa is an MSc student under the supervision of Dr. Anne Ellis at Queen’s University. Her work is focused on investigating clinical and biological manifestations of house dust mite-induced allergic rhinitis using the Environmental Exposure Unit (EEU) model.