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Science of Pandemic Tech
The emergence of new mutations in SARS-CoV-2 and their implications

Jun 29, 2021 09:00 AM in Pacific Time (US and Canada)

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Katrina Lythgoe
Katrina is a Group Leader and Sir Henry Dale Fellow at the University of Oxford. She studies the evolution and epidemiology of viruses, and up until a year ago she mainly focussed on viruses causing long-term infections, like HIV, hepatitis C virus and hepatitis B virus. Over the last year she has also been working on SARS-CoV-2, including developing epidemiological models forecasting its spread, and looking at the genetic diversity of the virus within individuals, and how much of this diversity is transmitted between individuals.
Tyler Starr
Tyler is a postdoctoral fellow in the lab of Jesse Bloom at the Fred Hutchinson Cancer Research Center in Seattle, Washington. Tyler studies the molecular evolution of proteins in viruses and immunity. Over the last year, he developed an experimental “deep mutational scanning” platform to comprehensively map the biochemical impacts of mutations in a key domain of the SARS-CoV-2 spike protein. These maps enable rapid evaluation of the potential phenotypic consequences for newly observed SARS-CoV-2 variants, and are being used to evaluate and design antibody and vaccine therapeutics.