Establishing dynamic spheroid cultures as mini-tumour models for treatment evaluation

In this presentation, the process to establish three-dimensional spheroid models in rotating bioreactors, and benchmarking their suitability to study cancer treatments will be discussed. These mini-tumour models aim to bridge the gap between in vitro studies and the human in vivo system, by mimicking cancer cell behaviour in vivo better. Once established, each model is characterized in terms of growth and viability characteristics, after which it is benchmarked through treatment with a standard chemotherapeutic drug.

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