Sepsis can and does affect people of all ages. The very young and those who already have a chronic health problem or a compromised immune system are at higher risk of developing sepsis. But people over 65 years old, particularly those who have health issues, are even more susceptible to sepsis than any other group. According to a study published in 2006, while people aged 65 years and older make up about 12% of the American population, they make up 65% of sepsis cases in the hospitals. This session will discuss the pre-acute phase from symptom onset to diagnosis and associated patient and caregiver experiences with symptom appraisal, self-management, barriers, and inter-personal interactions.