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Maternal and neonatal effects of in utero exposure to perfluoroalkyl ether acids in the Sprague-Dawley rat
Join us on January 15, 2020 at 10 am Pacific / 1pm Eastern to hear about Dr. Justin Conley's research on emerging PFAS compounds and mixtures.

Extensive work has been done investigating the toxicology and epidemiology of legacy, straight-chain perfluoroalkyl substances (PFAS). These compounds have now largely been removed from commerce because of concerns over widespread environmental contamination, relatively long environmental and biological half-lives, nearly ubiquitous exposure to humans and wildlife, and numerous adverse effects associated with exposure. Due to advancements in environmental chemical monitoring, additional PFAS compounds have been identified and quantified in surface water, ground water, drinking water, and human serum. One subclass of PFAS that have recently been identified are perfluoroalkyl ether acids (PFEA). Examples include the perfluoroalkyl ether carboxylic acid GenX and the perfluoroalkyl ether sulfonic acid Nafion byproduct 2. GenX is currently used as a replacement for PFOA in the industrial manufacturing of non-stick coatings and Nafion byproduct 2 is a byproduct of industrial manufacturing of high-performance electrochemical membranes. Notably, although GenX and Nafion byproduct 2 have been recently detected in elevated concentrations in river water and drinking water, there are little or no peer-reviewed, published toxicity studies for comparison to the legacy PFAS. Further, despite biomonitoring data indicating widespread human exposure to multiple PFAS, there is little to no in vivo toxicity data regarding mixture-based effects to inform cumulative risk assessment. This webinar will cover recent data generated from laboratory rat studies on the adverse maternal, fetal, and neonatal neonatal effects of in utero exposure to emerging PFAS compounds individually and as mixtures.

For more details, please visit https://www.healthandenvironment.org and select this webinar from the list at the bottom left of the homepage.

Jan 15, 2020 10:00 AM in Pacific Time (US and Canada)

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