Gene therapy vectors such as adeno associated virus (AAV), vaccine carriers like lipid nanoparticles (LNPs), and their payloads are keys to targeted therapeutics delivery. Sample integrity and recovery remain the biggest challenges during production and scale-up. Big Tuna is a fully automated, versatile buffer exchange and concentration platform. We will discuss new methods tailored to each gene therapy vector type, and these finicky samples can now be exchanged and concentrated in a higher-throughput manner. In this seminar, we will demonstrate how Big Tuna can exchange samples faster and more consistently without compromising sample integrity or recovery.
This webinar will cover:
• AAV sample concentration from dilute solutions
• Ethanol removal following LNP production
• Salt removal from nucleic acid samples