Adeno-associated virus (AAV) formulation selection and stability characterization is an underexplored space due to low assay throughput and high sample volume requirements. To push the frontier in these areas, we started with Big Tuna’s ability to concentrate and buffer exchange many AAV samples in parallel and into multiple formulations. A suite of formulation conditions was then tested using Uncle’s new application for studying AAV stability and aggregation. Combining automated buffer exchange and AAV stability measurements in high throughput and on a small scale makes Big Tuna and Uncle the perfect guides for mapping out the AAV formulation space.
- Learn to assess AAV stability based on genome release, capsid stability, and aggregation
- See how to automate buffer exchange and add degrees of process control that are not possible with manual approaches
- Create strategies to do more analytical measurements with less sample when the right tools are available