Professor Ian Tomlinson ( University of Edinburgh)-
Why are cancer genes tissue-specific? Puzzles and insights from inherited colorectal cancer
Abstract- One of the major unanswered questions in cancer is why some driver genes occur across multiple cancer types, whilst many others with ubiquitous expression are restricted in their effects to certain tissues. There is unlikely to be a single explanation for this phenomenon, and clues are likely to arise from several differences approaches to the problem. In this presentation, I provide recent evidence from inherited and sporadic colorectal cancer about the tissue-specific effects of driver genes involved in the repair of DNA in all call types. Some likely explanations for driver gene tissue-specificity are provided, but other new data emphasise that those explanation is incomplete.
Session Chair- Professor Adrienne Flanagan