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Pathology Grand Rounds April 2021- Sponsored by PathSoc & The Jean Shanks Foundation
Professor Ian Tomlinson ( University of Edinburgh)-
Why are cancer genes tissue-specific? Puzzles and insights from inherited colorectal cancer

Abstract- One of the major unanswered questions in cancer is why some driver genes occur across multiple cancer types, whilst many others with ubiquitous expression are restricted in their effects to certain tissues. There is unlikely to be a single explanation for this phenomenon, and clues are likely to arise from several differences approaches to the problem. In this presentation, I provide recent evidence from inherited and sporadic colorectal cancer about the tissue-specific effects of driver genes involved in the repair of DNA in all call types. Some likely explanations for driver gene tissue-specificity are provided, but other new data emphasise that those explanation is incomplete.

Session Chair- Professor Adrienne Flanagan

Apr 14, 2021 09:00 AM in London

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Professor Ian Tomlinson
@University of Edinburgh
Professor Tomlinson joined the University of Edinburgh in Autumn 2019 as Charles and Ethel Barr Chair of Cancer Research and became the Director of Edinburgh Cancer Research Centre (including Cancer Research UK Edinburgh Centre) in January 2020. He was previously Director of the Institute of Cancer and Genomic Sciences at the University of Birmingham, having worked before that at the CRUK London Research Institute, University of Oxford and the Institute of Cancer Research. His research interests lie in discovering and functionally characterising cancer driver genes, especially germline variants that predispose to cancer. He also has a longstanding interest in cancer evolution, derived from his PhD project in population genetics, with a specific interest in the relative contributions of selection and mutation to cancer growth. Ian’s work focuses on colorectal cancer, but extends to several other cancer types. He is especially keen to integrate work across a variety of biomathematics.
Professor Adrienne Flanagan
@University College of London
The session will be chaired by Professor Adrienne Flanagan who is the the President of the Pathological Society of Great Britain and Ireland.