George Perry, PhD ▪ University of Texas at San Antonio
Pathology in Alzheimer Disease: A Protective Response?
Introduction: Xiongwei Zhu, PhD
Case Western Reserve University
Dr. Perry will present the pathology of Alzheimer’s disease from the pathological perspective that places plaques and tangles as biological responses to metabolic and oxidative stress rather than the cause of disease. He will review his work demonstrating oxidative stress is the first abnormality of Alzheimer and that mitochondria, autophagy and metal redox chemistry are its source. In this mix, amyloid-ß reduced oxidative stress through Cu/Fe redox chemistry. This places the pathology as potentially protective, like inflammation, explaining why thirty years of focus and eventual success in removing pathology has not produced meaningful benefit for patients.