Normally, scholars and laypeople explicitly or implicitly distinguish between "cultural" and "religious" forms of vaccine hesitancy. In order to address urgent public health dilemmas that have become quite stark during the current pandemic, it is worthwhile to reflect on some of the shared roots of these phenomena. Many questions arise from these reflections: from the vantage point of a hesitant individual and community, what sort of world is being imagined as the problem, and the solution? What can the study of religion contribute to our understanding of hesitancy related to COVID-19 vaccine hesitancy in particular? Or, to look at this matter from a different angle, what do we learn about religion/spirituality by thinking about "conspirituality"?