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TN2 online lunch series - 15 April 2021
- 12.30 - 13.00 PM
Drs. Kinki Jim (Amsterdam UMC, location VUmc) - Central sensory neurons and bacterial meningitis

- 13.00 - 13.30 PM
Prof. Michael Heneka (University of Bonn Medical Center, Germany) - Innate immune activation in Alzheimer’s disease

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Contact information: conference@tn2.eu

Apr 15, 2021 12:15 PM in Amsterdam

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Kinki Jim
MD @Amsterdam UMC, dept. of Medical Microbiology/dept. of Neurology
Pathogenic bacteria can infect the central nervous system via the cerebrospinal fluid (CSF), leading to devastating consequences. How pathogens are detected and eliminated from the CSF is incompletely understood, though resident and circulating immune cells certainly play a role. Although peripheral sensory neurons can detect intruding pathogens, it is unknown whether pathogens invading the CSF in the context of meningitis can be detected by non-immune cells in the vicinity. In this lecture/presentation, I will discuss how interoceptive sensory neurons contacting the cerebrospinal fluid (CSF-cNs), but not epithelial cells, detect and combat pathogenic bacteria known to cause meningitis in humans.
Michael Heneka
Prof. @Dept of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical center, Bonn
The accumulation of neurotoxic amyloid beta peptides along with neurofibrillary tangle formation are key pathological hallmarks of Alzheimer’s disease. The brain has been considered as an immune-privileged organ, however, increasing evidence from translational, genetic, and pathological studies suggests that activation of distinct innate immune pathways are a third important disease hallmark which, once initiated, actively contributes to disease progression and chronicity. Microglia play a pivotal role in this immune response and are activated by binding of aggregated proteins or aberrant nucleic acids to pattern recognition receptors. This immune activation leads to the release of inflammatory mediators, but also distracts microglia cells from their physiological functions and tasks, including debris clearance and trophic factor support.