ICMAB PhD Thesis
by Zhongrui Luo, Nanoparticles & Nanocomposites Group, ICMAB
"In vivo interactions between food availability and nanoparticles in Caenorhabditis elegans"
Abstract: During the last decades, nanoparticles (NPs) have been widely used in various fields, especially in medical applications such as drugs, imaging agents, and drug-delivery carriers. However, they also raised public concerns regarding the potential adverse influences on human health. Collective efforts from worldwide researchers in materials and biological science have been invested in investigating the toxicity mechanisms of different NPs.
In this thesis, we dedicated major efforts to apply (Caenorhabditis elegans) C. elegans as a robust and simple model organism for toxicity assessments of assorted NPs. The general objective of this thesis was to study effects of food availability on nano-bio interactions between superparamagnetic iron oxide nanoparticles (SPIONs) or 10 nm AuNPs and C. elegans, and prove that this small animal can be used to study alimentary effects.
Supervised by Anna Laromaine, NN group