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TN2 online lunch series - 18 March 2021
- 12.30 - 13.00 PM
Dr. Wia Baron, (University Medical Center Groningen) - On the road to a remyelination therapy in multiple sclerosis

- 13.00 - 13.30 PM
Prof. dr. Elly Hol (Utrecht Medical Center Brain Center) - Astrocytes in brain diseases: role in synapse dysfunction and cognitive impairment

Read more below or on our website www.tn2.eu

Contact information: conference@tn2.eu

Mar 18, 2021 12:15 PM in Amsterdam

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Wia Baron
Dr. Associate Professor @University Medical Center Groningen
Loss of central nervous system myelin, and the failure of remyelination by oligodendrocytes, contributes to the functional impairment that characterizes the chronic inflammatory and neurodegenerative disease multiple sclerosis (MS). Since incomplete remyelination will irreversibly damage axonal connections, treatments effectively promoting (re)myelination are pivotal in precluding disease progression. Although the reasons for remyelination failure are likely multifactorial, one of the major impediments to successful remyelination is the altered lesion microenvironment. Our findings suggest that the extracellular matrix protein fibronectin accumulates within MS lesions, and forms aggregates.
Elly Hol
Prof. dr. @Department of Translational Neuroscience, UMC Utrecht Brain Center
Astrocytes form functional units with synapses and closely interact with microglia. In neurodegenerative disorders astrocytes change morphology and function. Hallmarks of these reactive astrocytes are hypertrophy of the cellular processes and upregulation of the intermediate filament proteins GFAP and vimentin. These proteins form highly dynamic cytoskeletal structures that are involved in cell signalling. We have shown in a mouse model for Alzheimer’s disease that reactive astrocytes have an altered expression of genes coding for extracellular matrix proteins, neuron-supporting genes, and immune response-related genes.