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Prof. Nick Young presents Quantitative Proteoform Biology Reveals Mechanisms of Transcription Regulation
Nuanced regulation of gene transcription is essential for higher eukaryotes. The development of methods for the precise quantitation of histone proteoforms have revealed that both dynamic and persistent regulation of transcription is achieved in part through single-molecule combinations of post-translational modification acting synergistically or antagonistically. Extension of these methods into in vivo models have revealed differential spatial distributions of proteoforms and changes that occur over lifespans.

Apr 22, 2021 11:00 AM in Eastern Time (US and Canada)

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Dr. Nicolas L. Young
Asst. Prof., Verna & Marrs McLean Department of Biochemistry & Molecular Biology @Baylor College of Medicine
Dr. Young earned a BS in Chemistry from the University of California, Berkeley, and he obtained a Ph.D. working at both in his own lab at Lawrence Livermore National Laboratory and with Carlito Lebrilla at UC Davis. In 2008 he joined the laboratory of Ben Garcia in the Molecular Biology Department at Princeton University as an NCI postdoctoral fellow. In 2012 became the Director of Biological Applications with Alan Marshall at the National High Magnetic Field Laboratory. In 2016 in joined the faculty in the Verna and Marrs McLean Department of Biochemistry and Molecular Biology at Baylor College of Medicine in Houston, TX. His work focuses on a more complete understanding of the regulation of the genome through the use of Top-Down Proteomics to observe the co-occurrence of multiple post-translational modifications on the same single molecule. These single molecule combinations, or proteoforms, are important signals that modulate gene expression. More at https://bit.ly/3mfwl5D