The prevalence of cannabis use for purported medical indications increases in states that adopt medical marijuana laws. A firm understanding of the association between cannabis use and substance use disorder treatment management is critical to the modern practice of addiction medicine. This didactic presentation will review literature related to cannabis use and other substance use disorders. A discussion addressing modern addiction medicine practices and implications for patients who use cannabis will be provided. The bulk of the presentation will introduce several practical clinical approaches that clinicians can use when providing medical care to patients who use cannabis, including those who have been issued cards authorizing the possession and use of cannabis for purported medical indications. We will conclude by introducing a motivational interviewing technique that can be used to evoke a patients’ own motivation and commitment to change their cannabis use.