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Journal Highlights - Immunogenomic profile of colorectal cancer response to immune checkpoint blockade
1. Hypermutated CRCs are enriched in cytotoxic and proliferating CD8+ T cells
2. Patients benefiting from immune checkpoint blockade show signs of active immune escape and are enriched in CD74+ macrophages
3. CD74+ macrophages form high density clusters where they interact with cytotoxic and proliferating CD8+ T cells
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