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ONCO CT-4 - Shared screen with speaker view
Samuel Joo
25:10
You are considering the dose smaller than inflection point in dose response curve. How about the point larger than inflection point
Samuel Joo
26:00
Correct
Samuel Joo
26:18
HOw do you know where you are in the dose response curve?
Guillermo Lorenzo
26:54
Very interesting work! Out of curiosity, Have you explored the combination of drug pharmacokinetics in humans with you ideas of fragility/antifragility? That is, how would the time changes in drug concentration in the tumor tissue affect your conclusions in this work?
Virginia Turati
27:02
Really cool findings Jeff!
Jeffrey West
29:18
Great point Guillermo. This is just considering the “PD” part, but the “PK” dynamics will certainly influence the outcome. I would love to look into this soon
Guillermo Lorenzo
29:57
Thanks ! Looking forward to the PK/PD extension!
Jaewook Joo
44:53
how much do we understand the radiation effect on immune response? How does the radiation redistribute the ratio of effector to suppressor?
Heiko Enderling [he,him]
46:13
Great question Jaewook. We irradiate different immune cells in vitro to get their radio sensitivity. Based on these, we simulate their radiation response
Heiko Enderling [he,him]
46:30
Which of course leads to the shifts along the x axis that I showed.