Welcome everyone! Please make sure your chat is set to “Everyone” so we can all see your messages 🙂

I don't see that I have an "everyone" option on the drop down... odd?

chat disabled -- can't hit everyone

Chat should work now!

multiple folks saying so in Q&A

Howdy from Richmond, VA

Yes all ok now! Good evening from the UK.

Working. Thank you.

FDNP

HI everyone - Stuart, FL

ND

Hello everyone! So good to have you all here 🙂

Nutrition professional, CNS

hi

ND

MD

Hello from Boca Raton

Kerri from Savannah

FDN-P

MD

Hello from Denver!

FM PT

RDN (func med nutritionist)

DC, LAc

I still don't.

Molly Fleming ND

dc

Hello, hello, from Costa Rica!! :-)

Stuart, FL as well.

Oh well. I am here from CT :)

FDN-P from Los Angeles!

Good Morning from the early morning of Friday from Australia

Hello from WV

Functional and Integrative Nutritionist in Florida

Health coach

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Np

Greetings from Seattle!

Functional Health Coach & Nutritional Chef

Hello from San Francisco (Digital Nutrition Platform)

Nutritional Professional for Winston-Salem NC

Seattle

functional medicine health coach from Houston

Nutritionist

MD, MSN Gastroenterologist from Florida

Functional nutrition resident!

Page and Harvey Health and Wellness coaches

Hi From South Africa

Personal interest! Trying to solve my gut issues

Hello! Deena Neff, MD from Oakland, CA

hi joining from Toronto

I am a MD

Christine, CDCES

panelists can't chat to everyone

Functional Diagnostic Nutrition Practitioner from CA

Hello from Little Rhody

Hello from Redondo Beach

Hi everyone! Functional Nutrition from MASS

I'm a person with low, 5.5 akkermansia! 🙁

Hello from this Brain-gut axis nurse researcher in Maui!

Holistic health & brain health coach in Tucson

hello from northern VA

Hi Everyone!

There is a lot of feedback on the sound. Not sure why. It comes and goes. Is it only o

So great to see you all here

it's fine here

Audio is fine

sounds great

must be me🙂

fine here

If you haven't listened to Dr Kara's podcast with Dr. Cutcliffe -- this is what spurred the webinar! So much to talk about: https://www.drkarafitzgerald.com/2022/09/01/latest-evidence-and-clinical-applications-of-akkermansia-with-dr-colleen-cutcliffe/

I am a person with high akkermansia (5.44e6)

Just a reminder to pop your questions into the Q&A box on the left and set your chat to “Everyone” by clicking on the blue box right above the chat box

Yes, that was a great conversation. In that podcast Colleen mentioned there are polyphenols that may possibly hinder Akkermansia. Would love to hear more about that..

Which is her book please?

@elba - Dr. Fitzgerald's book is called Younger You

thanks

Here’s the book - https://youngeryouprogram.com/book/

Kara's recemt Book: https://youngeryouprogram.com/book/

Unbelievable Dr. KF!

Your story is why we started this company!

Fantastic results Kara - did you see shifts right away or after the 3 months? I have had my mom using Pendulum for almost 5 months & she just told me she felt a major positive shift after about 4 months

Dr.KF did you take her A1c before and after the use of Am?

I did a viome test and have zero akkermansia (and actually a less diverse microbiome than I thought I had). I haven't taken antibiotics in years.

Mine is very low and my daughter had antibiotics when she was a baby and now 18 years old and has really struggled with weight.

I am on month 2 myself so excited to see how it goes

My GiMap says 4.12e4. Curious to learn what is optimal

A1C was 5.6; now 5.3! woot!

what's the myth about Akkermansia and multiple sclerosis risk...

1,5%-5% of your microbiome

one month for me to see sugars consistently in the 70's. (FBS- morning)

Deb M - you and are the same. I am also a C-section bottle fed kid with lots of Abx in my past...

Dr. Fitzgerald which Pendulum product did you use?

Wow - 1 month is fabulous!

possibly happened earlier, but I just started measuring consistently...

Thank you!!! Hoping there will be a replay. So sorry I have to leave, as this is awesome.

i started w glucose control, but now using just akker

what about if the stool test shows akkermansia is High 8.37e7 ?

I'd heard of Akkermansia but thought that it wasn't shelf stable. Very interested to hear how you've been able to manufacture a supplement version!

what diet best feeds akkermansia

@Sharon - thats a great question to pop in the Q&A!

what about high akkermansia?

I have a similar question as Katherine. What if stool tests shows Akkermansia is High 1.77e6 and the range is 100e1-5.00e4?

What is the link between high akkermansia and MS

One study showed antibiotic plus cadmium resulted in high Akkermansia

Could the Akkermansia be trying to correct a problem

amazing information here!

so fascinating... I just ordered Pendulum's Akkermansia nad can't wait to start... Kara's early observations are so encouraging

I have a lot of neuro patients and MOSTof my patients have high akkermansia

I had high akkermansia due to excessive matcha drinking. I stopped. And it went down

What is high? There are different norms between labs in US and Europe

There is a very high association of high methanobacteriaceae and high Akkermansia, ie. Methane SIBO or IMO, the new term.

exactly what my conclusion was

I use Vibrant Labs' Gut Zoomer

Lata, did u take the glucose product or plain alkermamcia

Kara I mean

I use Genova GI effects or GI Map.

I have client with Hashimoto's and high akkermansia

I have Hashimotos and my akkermansia is very low.

Exciting potential in longevity!

I’m sorry, did I miss what you said about WHY older people have higher levels of those bacteria ?

As I posted above, high Akkermansia seems to correlate with high methanobacteriaceae in stool and then methane SIBO/IMO on breath testing. Plain Bifido really helps these people with their constipation. I don't know if I would give these patients Akkermansia if it is already high??

that is the million dollar question. Are they turning older because they have the higher levels?

i understand your pause, Stacey. Might first address SIBO and gut integrity. then add. I would guess it could be surrogate info

Hi Paula - I see you raised your hand, did you have a question?

Has anyone looked at microbes within a High Grade Appendiceal Mucinous Neoplasm?

Dr. Perlmutter says that akkermansia and Vitamin D are intertwined. IBS and diseased microbiome - seems to not be favorable (bacto and akkermansia) - vitamin D levels dose dependent improves akkermansia. these bacteria in turn help regulate T cells. i’ve a lot of clients with low D levels and low akkermansia. - also breaking up inflammation and high leptin

Agreed about building an anaerobic lab - wow!

That sounds like an AWESOME IG Live!

I agree Karen

well said! That would be an opportunity of a lifetime!

well said! that would be an opportunity of a lifetime!

So is it safe to use even if MS patients have high levels of akromancia? I am really excited about this product but this statement is new to me. Is it safe for children? When is the new product with a more affordable price point will it be released? Is it well tolerated for people with histamine intolerance?

Love all of the chat discussions! Please do make sure you have set your chat to “Everyone” (blue box at the top of the chat box)

I had posted to only host and panelists by accident:

Mounjaro is GIP with GLP and outdoes Ozempic semiglutide for wt loss

Colleen was that using glucose control, ask or both?

High Akkermansia seems to correlate with high methanobacteriaceae in stool and then methane SIBO/IMO on breath testing. Plain Bifido really helps these people with their constipation. I don't know if I would give these patients Akkermansia if it is already high??

Has anyone looked at timing of vaccines and microbiome shifts?

Would increased concentrations of Akkermansia after supplementation be an important clinical endpoint? Or do you think it works more as a postbiotic, where colonic concentrations would be that important?

What about butyrate-that also stimulates L-cells to make GLP-1. What would be the advantages/disadvantages of Akkermansia versus giving butyrate?

great question mary

i think colonization does occur.

Did Dr Kara just use the Akkermansia and not the Glucose product ?

for some

As you said you are feeling difference between taking and not taking Probiotic. So it means that there is no permanent colonization?

compared to polyphenols

I only supplement akkermansia for 4 weeks with the rest of my protocol.

Polyphenols 🎸 ROCK

I had extremely high akkermansia and I had been drinking an excessive amount of matcha. I stopped, and it went down

would Urolithin A (from pomegranate) would help increase akkermansia?

What is the glucose product?

did you say matcha DECREASED akk?

Using polyphenols to support but not direct akkermansia yet

I ordered it a few days ago

It's on my shopping list!

have held off because waiting for a good quality product

Any coupons for trying the product? Had to ask.

i am expecting my order today

trying on myself before recommending in practice

I have a patient on it and not helping that much.

why did Kara switch from Glucose control to just A?

My apologies. Have doctor appointment at 4. Please send slides and recording and specials. Excited to make this accessible to several of my people and myself

Affordability pricing

I put one pt on it and she lost 30-40 pounds without trying

education

Would love to see weight management studies in those without blood sugar issues.

Yes-affordability

Unknow the prices

I drank the equivalent of probably 6 matches a day for a little bit - just out of boredom during pandemic … everything else on my panels were great. eliminated, and then went to one per day, and akkermansia got to normal level in 60 days

I thought I heard you say matcha decreases akkermansia. Is this true?

I also have a patient where it didn't budge her A1c

What do you think about Akkermansia company in Europe? As Pendulum seems not available in central Europe.

does anyone experience hypoglycemia on it?

the poll doesnt add to 100... its greater than!

I don't need anything else – I’m in!

Has there been any benefits with type 1.5 diabetics?

if you already have Akkermansia in your stool should you focus on feeding the current strain that you have

Sorry, that I am late. This may have been covered. Was the potential correlation with Akkermansia and MS addressed? Will there be a recording available?

Bronwyn - which product did you use for that pt?

which pomegranate extract do you recommend?

I started Pendulum about a month ago and seeing the results I want. I am preDM’ish controlled on Berberine and lower carb.

Hi Jason, yes we did cover this - you can catch it in the recording 🙂

Can we have the chat with the recording please?! So much that is interesting here.

protocol on which testing to administer prior to recommending, how to introduce akkermansia, dose, and when to test again. basically more education! thx

Nice, Dallas. It is quite satisfying. Especially as a clinician, I am sure you've tried lots of other interventions (as have I)...

@sue yes!! too much to absorb from the slides and to have to read all the chat from everybody!

Oh my gosh… that’s terrifying… did you say brain surgery to remove a brain parasite?!?

For me, berberine, chromium, vanadium, biotin, lipoic acid... the usual arsenal... really haven't made a difference for my sugar.

or, for that matter, my family members (who do what I ask them to) ;)

I thought acacia powder helped improve akkermansia

Kara and compared to Inositol?

Good question, Virginia. I didn't use inositol.

Should akk be used short term or long term?

Ok

And inositol seems super important in certain conditions- PCOS in particular

How does alcohol impact akkermansia?

Would be great to get starting weight/BMI for these case studies for reference.

Did she see an improvemnt in bone desity because inflammation might have resolved?

how long would you keep someone on akkermansia?

And short turnaround times - very exciting!

did her reverse her osteoporosis?

What are any drawbacks to taking this?

If you don't have time for all the questions maybe you can answer them in an email - probably lots of repeats?

Anti anti-indications?

Any suggestions as to what to do about HIGH Akkermansia?

Can you put that link here in the chat please?

https://pendulumlife.com/

UK available at Amrita

are you on Fullscripts

Why would one take just Akkermansia vs Glucose Control, and or GI Repair?

Need a part 2 and 3... 😂

Thank you so much!

Yes Sue! There is so much to cover in one short hour.

I think I asked like a year ago and got only response for UK which is not EU. But not 100% sure, might be something else.

Have to scoot. Stay well everyone. Amazing!

Why do you have to use a google sign in to sign to be a Pendulum Partner?

Thank you Geri! Keep en eye on your email for follow up goodies!

Just placed an order!

How often are you then re-testing via stool sample to ensure client doesn't move from low to high Akkermansia?

Any recommendations for stool sample products that are affordable?

Does akkermansia supp colonize or does one have to keep taking it?

Is there a practitioner side to the website where we can learn more?

With nutritional interventions and supplements it is enough once per 6-12 moths I believe. The changes takes a longer time.

Same wuestion as Laurie H…

How do you decide between glucose control and straight akkermansia?

does the discount work for recurring orders or just the first order?

what about the questions we put in Q&A?

slide says first month of product membership Julie

Thanks Laurie, my Q too... does it "stick" ...colonising potential post- X months supplementation?

https://pendulumlife.com/pages/healthcareprofessionals

Yes I believe the partner sign up page is via Google forms here: https://docs.google.com/forms/d/e/1FAIpQLSdRzg3xqT4vp6Wd9At_Kt-3aIHC5hpgbE7t3L3HVhffPuoJ4g/viewform

Any issues if used by someone with hashimoto's?

Since time is limited, is there a way to have all the questions answered and sent to those attending to their email?

Thank you for this discussion! I talk a lot about Akkermansia from foods and polyphenols in my book Immunity Food Fix. Great discussion and love to see a product available!!

We'll be following up via email to address the wealth of questions in the Q&A! Just not enough time here.

Sam yanuck in PLMI said last nite don’t give DHA without glutathione on board

Damage to biome and GI is know with glyphosate as well as gene changes (Aldo-keto) ...glyphosate does increase Akkermancia (https://pubmed.ncbi.nlm.nih.gov/33502259/)

Heat-killed Akkermansia is still effective?

paula, that's because it has a lot of double bonds so its vulnerable to oxidative stress

Thank you for this discussion! I talk about Akkermansia from foods and polyphenols in my book Immunity Food Fix. Excited to see a product available!

would you take both the Akkermansia and GI Repair at same time

Direct sign up link: https://bit.ly/3qzmUko

Thanks Kara

This was wonderful. Thank you for the great info!

Signing up on that link is the best way to get involved from an hcp standpoint! You do not need a google account to sign up for free!

Thanks for this!!! And thanks for making able to have this wonderful sounding product!

Good information, thank you

Thank you to all

Thank you everyone!

thank you so much!

Thank you all

Does Glucose control or akkermansia help type 1 diabetes?

great. good wishes

Thank you

Thank you! Excellent webinar!