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Discovery Lecture - Dr. Jain - Shared screen with speaker view
Duncan Smart
20:11
If you have any questions, please submit them here in the chat, and we will get to them at the end. Thanks!
Gaomin Feng
38:21
KLF-3 RNAi blocks daf-2 longevity. Does activating autophagy rescue daf-2 longevity in KLF-3 RNAi condition?
Eric Donahue (he/him)
54:22
What is structurally/functionally different about klf-1/3 vs klf-2 in c. elegans and mice, where that klf-1/3 had the lifespan phenotype, but we see this large role for klf-2 in mice? Is it simply the lack of myeloid cells in c. elegans, or is there something else?
Eric Donahue (he/him)
59:19
Or is murine klf-2 the equivalent of nematode klf-1/3?
Matthew Alexander
59:31
Do you know if there is an effect of myeloid KLF2 deficiency on blood pressure in response to angiotensin II, and might this impact the observed differences in cardiac hypertrophy/fibrosis?
Nick Markham (VUMC)
01:02:14
Is Klf2 suppression of macrophage activation specific to type of activation? M1 or M2?
Kris Burkewitz
01:02:34
In a worm without a true ‘circulatory’ system or dedicated immune cells, where do you think KLFs are functioning to regulate lifespan?
Nick Markham (VUMC)
01:09:37
Will intermittent fasting help me live long and prosper?