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Has there been any applicable treatments developed for brain chemistry disorders/schizophrenia as a result of the findings?
Roger Colbran (he/him)
I have a couple of questions….
Thank you so much for this great talk Dr. Tsien! I have 2 questions: (I) The modeling suggests that the oscillations get smaller and almost disappear after 72h. Do you see oscillations in the amplitude and the decay time of minis disappearing in recordings of cultured neurons? (II) Are homeostatic synaptic changes also linked to the changes in spike firing frequency in addition to changes in individual spike kinetics? Thank you!
This feedback loop where synaptic homeostasis leads to spike homeostasis exists within the same neuron. Implying that altered spiking in a presynaptic neuron would alter spiking in the downstream neuron. Do you think about this in terms of circuit homeostasis, and is there a separate feedback mechanism for a presynaptic neuron to homeostatically regulate its own spiking?
yes...and are both GLuA1 and the bCamKII responses following from the initiation of TTX (you'd see the same for shorter-lived application?) Similarly, is there a sense in which the overshoot ringing comes because of the extreme TTX application...would more physiological variations cause overshoots/oscillaitons?
Is the oscillation also observed in the neuron recovered from the inactivity?
Thank you so much! I really enjoyed the talk and learned so much.