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Does the normoxic/hypoxic phenoytpe only affect the birth rate of the cells in your model ?
What do you plan for the future ?
Has your (fairly complex) model provided some interesting results/insights that (less complex/previous) models have not?
(Also thanks for the talk Cicely- was just trying to write quickly so skipped the politeness :D)
Great question Sara… honest answer not yet, as we are yet to actually do any “experiments” on our model. I’m hopeful but only time will tell :)
OK thanks, I'll keep updated then
Hi Cicely! Thanks for the nice talk. I have a question about hypoxic cell---might be a stupid one. You mentioned that at some moment it will stop proliferation and acquire more motility, does that mean the adhesion betweem the hypoxic cell and other cells/vessels will reduce? (Sorry that I am not an expert on cancer topic...)
Great question Qiyao - so biologically speaking this is exactly what the Epithelial to mesenchymal transition is all about… however so far in our model we only incorporate this by increasing the random motility aspect of the ODE which is a little simplistic.
Ah, I see! Thank you very much!
Thanks for organising Bhargav!
Thank you for organizing!