The largest and most influential university systems of higher education are those of China and the US, respectively. Over four decades, they became intertwined and interdependent. Their decoupling would be a race to the bottom. With Sino-US relations mired in disagreements over trade and technology there is an urgent need for university leaders to ensure that educational and academic partnerships do not fall victim to geopolitical rivalry. In the current fragile world order of neo-globalization, Sino-US relations require a strategic stabilization. A new framework can capitalize on China’s civilizational emphasis on education with its massive talent in STEM fields, and the US’s university tradition of openness, debate and emancipation of the mind. Together they can better address global threats such as pandemics, climate change, poverty and inequality. The outgoing US administration cancelled key education exchange programs, restricted scientific cooperation, and created bottlenecks in study visa application approvals. The new US administration will focus on domestic issues but it has an opportunity to take several small but positive steps in education, technology, and health where universities have a major role to play in global peace and security. This talk will identify what might be done to improve US-China university cooperation for mutual benefit and the global common good.